I've been on Mounjaro for 4 months now. You normally start with an initial lower dose and increase the dose after a month. I lost 5 kg (~11 lbs) on the initial dose in the first month, and when I increased the dose, I also stopped smoking.
I've been smoking on and off for 20 years. I have stopped (and relapsed) many times, so I believe I can compare. This was a lot easier. I mean, I had cravings, but they weren't really that bad, and while the first week is generally the difficult part, I only had a couple of days with issues. I did not lose weight that month, though, which is fine as I would normally gain a lot due to compensating for cravings.
I increased the dose again and started losing weight. I guess some people gain weight when they stop using GLP-1. Even if that happens, I'm fine with stopping smoking without weight gain.
That's incredible! Smoking is the hardest one of them. Mainly because smokers tend to be skinny, as cigs kill your appetite (unlike alcoholics who tend to be fat) and all GLP-1 effects go together with the weight loss.
Congrats. Smoking is a bitch of a habit and extremely hard to quit.
Nicotine pouches (or even vaping) are astronomically less harmful than cigarettes and still work as appetite suppressors. As a bonus they are more convenient to use in public. Smokers should consider considering switching instead of quitting nicotine entirely if it's easier.
I don't know why you're getting downvoted, but I totally agree.
I used to smoke a pack a day for years, but switched to vaping in the 2010s when nicotine salt juice became more available. It was a massive quality of life improvement. Though initially this unlocked a much higher dose of nicotine I'd ever get smoking, I eventually brought it down and regardless my lungs were doing better.
Around 2020, I switched to the pouches and since then I'm down to using maybe like two a day if any at all. Since they are a slower delivery method, the nature of the cravings has changed too. I can easily hold off for hours or even days since they're less intense. I have zero desire to go back to smoking or vaping ever again. I've never experienced any oral health issues from the pouches either. X-rays on my mouth and lungs now show no damage.
The only thing I will say is nicotine itself isn't entirely harmless and can trigger some mild anxiety. It seems to be related to keeping blood cotinine levels in check.
I'd never recommend people start a nicotine habit, but I think we're at the point where it's not much worse than caffeine if you take it orally. There is some research out there about the potential benefits of both preventing dementia, but I won't link anything. People can argue about that somewhere else.
The trouble with the dementia prevention claim is that while the retrospective studies are promising, none of the RCTs really show results. You can argue this is because the RCTs don't dose enough nicotine early enough to matter, and that's likely true, but retrospective studies can turn up all sorts of phantom correlations. Right now I would say we don't know for sure, and I wouldn't recommend nicotine as a preventative measure.
I would recommend nicotine as a stimulant, though. It is a solid adjunct to caffeine.
I was a daily drinker for many years. A "1 or 2 cocktails in the evening" type of person. (And of course, 1 cocktail often meant 2 shots, so 2 cocktails = 4 shots a night.. looking back... yikes)
I started a GLP-1 in February of 2025. Lost a bunch of weight, etc.
What I wasn't expecting was that I'd have such an easy time dropping the daily drinking habit. I'm not convinced GLP's will help if you're truly addicted to alcohol to the point where you need AA and structured programs to break free. But I do think GLP's have the potential to give you the initial "kick" you need to drop the habit if you're otherwise motivated to.
In the first few months of starting the GLP-1, I remember losing enjoyment for eating (and drinking) a lot of things, especially unhealthy stuff (unhealthy foods/drinks tend to not combine well with GLP's). The taste of a cocktail wasn't as appetizing or appealing as it used to be, hard to explain.
Similar experience. Went through a phase of drinking once or twice a week. Started GLP-1, completely dropped the drinking habit to the point where there is zero desire of drinking.
Now, I wish it could do this for late night sugary snacks as well since that's my crux.
This was also my experience. I was a daily drinker, but once I started on tirzepatide I lost all interest. Even after I stopped taking the medicine, I still wasn't interested. I'll occasionally have a cocktail or glass of wine, but it's now a once-a-month sort of thing.
There is a point you made here "losing enjoyment for eating (and drinking)" that I think is The Key, but also not what people think when they hear it without experiencing it. Someone hearing that line might think it makes food "unenjoyable," as in "bad." That is not the case. It is "unenjoyable" as in "lacking in a joyful experience."
After talking with friends of mine who are similarly aged to me but have not had the major weight struggles I've had, I realized one of the biggest differences between us is not our drive or discipline (they envy me in many of these areas), it's in the sheer level of enjoyment that I get out of food and drink that they do not.
There are certain foods that, if I have them, they make me more hungry. I can't physically fit enough spaghetti or chocolate pudding into my mouth to satisfy my craving for it. My favorite beer feels glorious all the way down my throat and into my stomach; I can go from depressed to happy in 10 seconds just from that first gulp. And it's just those specific things. I'm not going to scarf down hard on lasagna or chocolate ice cream. While I enjoy whiskey, wine, cocktails, and other beers, I can have one in a night and be done.
There are also foods that are the opposite. I physically cannot stomach muscles or cuccumber. Putting cauliflower--in any form--on my plate is likely to start an argument. All leafy greens feel like a punishment; I can choke them down, unlike muscles, but I'm not going to like the person who made me do it.
But my friends without weight issues have never had these experiences with any foods. Food is just a way to avoid hunger. Booze is just a way to get drunk. There's no strong emotional connection to any of it.
And GLP-1 agonists completely remove that. I've heard it called "The Food Noise." It's basically a re-baselining of my relationship to food back to what should be "normal." Nothing has a feedback loop of pushing me to consume more anymore. Nothing gives me such strong revulsion that I can't eat it anymore. It's just food, on my plate. I don't even feel hungry, the only reason I'm eating it is because I understand at an intellectual level that I have to in order to not pass out in the middle of the day.
It just makes me eat less. I enjoy food every bit as much as I did before, just less often and in lower amounts. I still get hungry eventually and still want to eat and food tastes the same and if anything has a stronger emotional appeal than it did before because I eat so little.
I still enjoy drinking an IPA just as much, and really I enjoy it much more since I have one every few months instead of 5 every night. I could enjoy one every night, but I don't really need to have it, even though it would be delicious and the buzz is enjoyable, I just don't feel compelled to get it and I know it's not good for me. I knew before it wasn't good for me, believe me as the child of an alcoholic I knew it wasn't good to drink every night, but I did anyway because I had something inside pushing me to do it.
So maybe that is what you are describing, that thing that pushes you to do things you know are bad for you, and which you will regret immediately, but yet you feel like you have to do anyway. It's not enjoying something more, it's more like feeding withdrawal.
Overall I feel like there is someone in control now. I can just decide that drinking a beer every night is bad for me and not aligned with my goals and then I don't do it, and when I rarely think about it I'm just not a person who drinks alone anymore and my thoughts quickly move on to figuring out how to make croissant dough or looking for a scene to post to instagram or some work problem that has been bugging me.
Why don't you eat 5 entire pizzas instead of 5 slices? It's like that. One pizza seems like a LOT of food now. Three slices seems like too much. Before I could eat a whole pizza without even thinking twice. I look forward to it just as much, if not more. The first bite is just as good, but honestly seems better since I didn't just have a snack an hour ago. I ate like 5 Takis for a snack the other day and they were delicious and I really enjoyed it, but before I would have eaten the entire bag and not really even taken the time to taste them.
I would say it takes longer to get hungry even though I eat maybe 1/3 to 1/2 as many calories as I did before (that is to say 2/3 less than before). If I ate this little before GLP-1 I would have felt like I was dying and would have been thinking about food and hunger all day and night.
Yes you do fill up faster, and your stomach empties slower, so there is actually a physical 'being full' that happens with less food than previously.
I have heard a few very different experiences with GLP-1s, for some an almost magical relief from addictive behaviors, for others they didn't notice much on that front at all.
So much is about what is causing the behavior I would expect. GLP-1s don't change the way you think so much as breaking some of the trigger mechanisms.
Are you doing the action because you want to do it, or because your body is responding to that mild trigger that occurs, but your pavlonian response is so strong you can't differentiate.
The thing is, those trigger mechanisms break after weeks without doing them, whereas it is very hard to break them normally without some more extreme measure.
I'm in the latter group. I've had little to no weight loss from Ozempic because my issue is having a sweet tooth, not eating too much regular food. Yeah I fill up faster, but by the time I would fill up on cookies or something that's still a crazy amount of calories. So it hasn't really helped me to curb my weight. It has helped my A1c though, which is the main thing.
Without getting into individual physical differences that occur, expectation is a huge part of addiction and overcoming addiction. Rituals are very often a part of substance abuse for similar reasons. It sounds silly, but consciously placebo-ing yourself can be very effective for people trying to quit. "This medicine will cure my addiction" can be a very powerful mantra for people with a strong imagination.
I've heard very addictive personalities describe it as a light switch being turned off, people who have been on a whole host of different things across time.
Individual differences in medication response isn't just placebo.
Why make medicine at all if essentially you think you just have to convince people of fairy stories well enough for literally anything to work?
I'm surprised that this article doesn't appear to mention the RCT on semaglutide and alcohol use disorder by Hendershot et al. that was published in JAMA Psychiatry in early 2025 (though it's possible I missed it) https://doi.org/10.1001/jamapsychiatry.2024.4789
This was largely portrayed as a great result in the popular press although personally I think it was a bit of a disappointment given all the amazing anecdotes https://dynomight.net/glp-1/
What made it a disappointment? Over only 9 weeks, which is a very short time for habit changes to take hold, there were measurable, statistically significant effects. And at the highest dose was just 1mg / week for one single week at the end, where the maintenance mode for many is 2.4mg / week.
Seeing such an effect in just 9 weeks, 90% of that time being at low ramp up doses, is astonishing.
The results for how much people actually drank in daily life were basically zero. No effect at all. The effects you're talking about are for a weird lab experiment where they sort of had people sit there in the lab and drink (or not). A huge percentage of people declined to participate in that experiment, too, which makes causality non-obvious.
The effects you're talking about are for a weird lab experiment where they sort of had people sit there in the lab and drink (or not).
Where people on GLP-1s -- in a randomized, double-blind study, notably -- chose to partake of less. I cannot fathom how you dismiss this.
It's a 9 week study at very low doses, and already a significant measurable effect was seen. Now if this wasn't a double-blind study I would dismiss it, but otherwise yeah, it matters.
People who have drinking habits will take a long time to adopt new habits. I would never expect to see baseline behaviour changes in so short a time. But their non-habit desire for alcohol clearly was diminished, hence the lab outcomes.
When you have lots of non-randomized dropouts from a randomized trial, that greatly weakens the causal link. The results are effectively non-randomized.
Meanwhile the evidence from actual drinking levels was much stronger (far fewer dropouts) and showed zero effect. Before this trial was done, you may have predicted that there would be positive results for the lab experiment but zero results in ecological conditions. But I think that prediction would be quite unusual. For anyone who expected results in ecological conditions (like me), this was disappointing.
What do you mean? I was always under the impression that archives are for accessing a copy when the original is hard to access - this seems like the perfect use case.
Bypassing a paywall does sound a bit like piracy, if you think about it. This is what the commenter is referring to (tho in this case, I don't see a paywall on the article this end.)
Advertisements and web tracking feel like stalking. I’ll pay for content when the content providers respect my attention and privacy and not until then.
This isn't archive.org. Archive.is (and its many TLD equivalents) is explicitly for bypassing paywalls like this, and this is absolutely the intended use.
9 times out of ten it's because sites use cloaking and serve up all of the contents to search bots, but then paywall out end users, so it's kind of a hoisted by their own petard kind of situation.
And, I mean, people can choose to not follow those links. To the rest of us they're often very welcome, and we aren't subscribing to every random site for the once in a millennia worthwhile article.
The site existed for most of a decade before it had any particular paywall bypassing. It's an ondemand archival site that saves the DOM in such a way that redisplay is faithful, unlike archive.org.
It's a key resource in court cases for purely archival purposes and the fact that it bypasses paywalls is essential for its archival purpose to function.
Yeah, sure (sarcastic). And people mostly use torrents to share Linux distros.
The site/org has no office and is anonymously run virtually. Exists on random, essentially free for all TLDs, does not honour take-down requests, does not respect robots.txt, masquerades as the Googlebot...
...yeah, I happen to have not been born yesterday so I'm not going to play along with a fiction.
Nothing I said was rude or adversarial, so not sure why you decided to be rude and adversarial here.
My sarcasm was to the purported original goal, when it has always, since day one, been a fake Googlebot known, again since day 1, as a circumvention of paywalls for sites that cloak.
well if you declare that nothing you said was rude (i.e. no sarcasm, which is rude) or adversarial, then I similarly declare that nothing I said claimed otherwise :) so what are you talking about, then?
When giant IP corporations violate IP, that's very different from Joe Rando watching a movie for free. It's way worse, on multiple levels, for rule-makers to break rules than for ordinary people to.
> It's way worse, on multiple levels, for rule-makers to break rules than for ordinary people to.
The purpose of the system is what it does. Yet the system routinely persecutes ordinary people for this criminal offense while giant IP corporations just treat it as an opening move in corporate deal-making.
It's mostly appetite suppressing. Affects the perception of hunger and the brain/reward function of eating, which must also be part of what also helps for drug and alcohol addiction.
It IME doesn't act like an anti-depressant/SSRI which can affect your enthusiasm/desire for your job.
But what if this self-described obsession translates into burnout? Does it actually make you good or just work more compared to your peers? Can you maintain it for the rest of your career?
(I'm just concerned; I've seen many people good at and super into their job end up with burnout, often multiple times because they keep thinking "I used to be good at this!", "I enjoy this!", etc instead of accepting that it was never sustainable in the first place. I suspect people's nervous systems etc are more resilient in their 20's, which is why most people with burnout only start to run into it in their 30's)
Another N=1, I've noticed zero impact on my desire to engage in my normal obsessions while on GLP-1.
What GLP-1 did (initially) was give me horrible insomnia that peaked a couple of days after taking the injection so I had to time my dosage so that I suffered through that on the weekend. That got better over time and eventually went away after about 6 weeks.
Regardless, as another poster mentioned, it's a weekly injection and if you don't like the effects you can stop taking it.
I was excited about effects like this and think they’re entirely absent unless you’re obsessed with food-related app development or something else related to appetite.
Something that has been hinted but not explicitly said: are these drugs performance enhancers? Like the same way you would take Ritalin you'd take these to curb your time wasting habits?
When the research comes in, I will be surprised if they are a performance enhancer outside the health benefits.
Meaning, it is performance-degrading to be overweight. When you remove that? you sleep better you breathe better you move better and therefore think better.
If they are directly performance enhancing, it is in an extremely subtle way- far less than a soda’s worth of caffeine.
For me they absolutely have been performance enhancing. Previously, especially in the afternoon it was hard to concentrate due to the constant cravings / constantly thinking about needing to eat something. These thoughts are completely gone, I can concentrate for hours and hours without needing to eat something. I have always only been mildly overweight, but these thoughts have been constant before I started Wegovy.
Anecdotal, but since I’ve started Zepbound, I’ve lost 110 pounds. In that same time period, I’ve paid off and cancelled all my credit cards (except for one, which I pay off every month), filed taxes for the last five years, got a CPA on retainer, and have fixed several pressing issues around the house that I’d been studiously ignoring as they got worse.
A major part of this story I think is especially important, the last time this sort of thing happened was about a decade ago, when I lost 90 pounds without any medical intervention. At that time I learned to code, fixed up my credit, and went from being front line technical support to junior software engineer. Quite a transformative time in my life.
I think curing my sleep apnea due to substantial weight loss means I sleep better, so I just feel more ready to tackle the things the world throws at me. Weight loss is a skill I had, but it required absolute commitment to avoiding sugary foods, eating right every single day, and as soon as I strayed the weight would creep back up over the course of a year or two.
It makes me think of the huge immeasurable economic costs that are happening in the shadows because of obesity, how many people like me are there other aren’t achieving our full potential because we’re just too tired and have too much brain fog to seize the day?
> I’d already understood addiction to be a treatable disease, not a personal failing. Still, these scans helped me appreciate how deeply addiction is rooted in neurobiology. A mere photograph of alcohol—to say nothing of a sip—was enough to send a person’s reward centers into a frenzy.
Ban alcohol advertising now and I’m not kidding or being hyperbolic.
I believe all the stories here about how these drugs helped with their addiction. However I will say I have not experienced this with food addiction which is interesting. I definitely eat less, but when I am hungry I'm still just as likely to eat peanut butter cups or french fries.
Seeing all these articles and studies touting GLP-1s as a magic additive to enhance health and well-being has me so skeptical that there haven't been any major downsides found yet. I guess long-term studies are necessary in order to really understand what we're getting on here.
I would love for it to be miracle it appears to be, since I hate trying to maintain my desired weight. I don't qualify for GLP-1 due to my BMI being too low, but I sure would like to stop the constant cravings for food and my love of beer. Everyday feels like a struggle to maintain a healthy lifestyle.
GLP-1s are the greatest medical innovation of the past decade. Top three, at least, mRNA might give them a run for their money.
There are known side effects, mostly gastrointestinal issues, and they don't work for everyone. That being said, I'd recommend you make your own risk assessment and consider getting on GLP-1s if you have the cash to spare. You might find that GLP-1s increase your quality of life so much that it's well-worth it (or that you get terrible nausea and immediately quit, and then you no longer need to wonder).
Potential risks have to be weighed against potential benefits. There are robust RCT results showing GLP-1s reduce all-cause mortality, major cardiovascular events, and stroke among patients with obesity or T2D by 13-14%, and suggestive evidence that some of these benefits apply to non-overweight people, though this hasn't been confirmed in RCTs and is likely smaller in magnitude.
"Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials": https://www.sciencedirect.com/science/article/pii/S266666772...
One reason to believe that cardiovascular benefits might apply to non-overweight people is that among the available evidence on overweight and obese people, weight loss doesn't seem to explain all benefits. See Figure 1 or the analysis section of the SELECT trial.
The main plausible long-term risk is thyroid cancer. Data from a meta-analysis of RCTs suggests a 55% (large error bars) increase in thyroid cancer risk.
This is concerning, though it's worth noting that thyroid cancer is rare (1% lifetime incidence) and unlikely to kill you (98% 5-year survival, 99.9% when caught early). No studies have linked GLP-1s to a statistically significant increase in cancer-related mortality. I don't want to be too confident because RCTs have not yet shown this and I'm not an Eli Lilly shill, but cohort studies suggest GLP-1s are associated with reduced risk of other cancers. This is a good overview:
Thanks for the thorough answer. I'm going to ask my GP and oncologist about the possibility of going on it just to see what it's like. I sure would like to drop 10 pounds and want less beer.
Smoking addiction is way harder to cope that alcohol, only surpassed by opioid. In any case a rigorous study must be performed as nowadays media hype articles about GLP1 drugs mention decline of supermarkets and increased profits by airlines because a few people lost 5-10kgs.
It’s not the cure. It’s temporary suppression. I re-sold few times monthly dose of Mounjaro and the buyers catapulted to same bad habits in no time when the last dose stopped working.
Like any medicine, it's something that is intended to be prescribed by doctors to be used under supervision, rather than just taken by people ad-hoc at a random dosage hoping for a miracle.
And as for cure rather than suppression - yes, according to that definition, no medicine that is intended to be taken indefinitely to manage a condition is a cure. But nevertheless, high blood pressure medicine, statins, anti-inflamatories, HIV antiretroviral therapy, and many other drugs have saved many millions of people from an early death. We should keep looking for one-off "cures" for all conditions, but let's not limit ourselves to them.
This is why on paper nobody is prescribed these drugs until they have followed a program to change lifestyle things like diet. You mention "re-selling Mounjaro" - which implies they just took the drugs without the programs, is that correct? Did you expect anything else?
But for many it's considered a shortcut and there's a big network of dubious online shops and weight loss clinics that sell it. It's not unlike crash / fad diets in that regard.
Most people would already benefit from lifestyle adjustments, but those are hard to do for most people - for starters, most people don't even have regular eating habits to begin with, no baseline to even make adjustments to.
Why? Statins are one of the most well studied drugs in existence. Most people have no side effects, and the long-term benefits are incredibly straightforward - on par with blood pressure medication.
Blood pressure is a often a side effect of being overweight. But only one side effect of many. Losing weight gets rid of all side effects, not just one.
"diet" implies a temporary change to achieve a certain goal. However, "changing your diet" has long term permanence in it. But this is hard for a lot of people because they don't have a fixed diet to begin with, instead just eating whatever whenever they're hungry. Same with exercise, people need to make that into a habit.
But forming habits / making lifestyle changes is hard. And when people hear they can just take an injection instead of make lifestyle changes they're like oo, easy!
The injection doesn't mean you don't make lifestyle changes. People have this delusion that GLP-1s just make you lose weight.
They don't. People on GLP-1s lose weight the same as you or I, through diet and exercise. It just makes it easier to build those habits.
Which I think reveals the obvious. Diet and exercise ARE NOT root cause solutions. Meaning, the root cause of obesity IS NOT eating too much. Rather, it's a propensity to eat too much. And, in that regard, GLP-1s are a root cause solutions, whereas diet necessarily is not.
Same here when I start/stop Mounjaro except I continue to enjoy exercise. Though I'm probably just kidding myself that the exercise is undoing the naughty food
The only way I found to reduce cravings is to be a hermit because there is food absolutely everywhere all the time
This is exactly my experience. The only time I’ve been able to consistently lose weight was during the pandemic, when I could both work and socialize from home and strictly regulate what food came into my apartment, and when I’ve been on tirzepatide.
Relying on exercise expenditure to outrun dietary intake is a losing strategy because exercise is not an effective way to create a caloric deficit. However, it may be one of the most effective ways to defend one.
Dropping alot of weight rapidly can lead to gallbladder issues. If you're on a GLP-1 please look into this and ask your GP about potentially putting you on Urusodiol.
I saw a thread on reddit where a GP chimed in and mentioned that he was giving urusodiol to all his patients at the same time as GLPs, to help prevent the associated issues.
Either way, modern science is great. Just do your research.
It does seem like a lot of doctors prescribe GLP-1s without any corresponding education on the dietary changes one should make while on them. A friend of mine's mother was hospitalized briefly because she was basically starving herself of proper nutrition while on GLP-1s.
Since I already knew that rapid weight loss is very unhealthy, I intentionally eat very nutrient dense foods in order to keep my weight loss in a reasonable range.
Expecting the subset of people who are obese due to inability to ignore their bodies bad signals to overeat, to have the same discipline in the opposite direction, seems foolhardy.
Every time these come up on HN everyone is willing to share their positive anecdote. What are the negative experiences that come with GLP-1s beyond relapse after stopping? I need both sides before I'd consider encouraging anyone to try it.
Rapid muscles loss, unless you are careful and managing it. In my case muscle loss led to increase, not decrease, of the lower back pain related to the crack in one of the vertebrae there. I believe that loss of core muscles increased load on the spine and caused pain. Once I started doing core exercises and cut down on dosage, pain returned back to pre glp1
Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.
Eli Lilly has taken to calling GLP1s "anti-hedonics" as well
I had an experience similar to the article. Over 18 months, I lost about 85 lbs on Ozempic and Retatrutide. I went from struggling to walk past beer at the at the supermarket - giving in about 50% of the time - to having almost no desire to drink. I only one or two beers every few months. I haven't had a drink alone in two years, and my total alcohol consumption in that entire two year period is less than what I used to drink in a single week.
During this same period, I left an abusive marriage and started exercising extensively. While the causes are complex, I attribute the loss of desire to drink primarily to the GLP-1. Subjectively, I now see drinking as a distraction from programming and other things I enjoy. This feels like my early 20s, when I saw getting drunk as a waste of time, rather than later years when I pushed for another round.
I've found some basic lifestyle changes to be way more effective at weight-loss and inducing well-being than a drastic chemical therapy like Ozempic. Imbibe at your own risk.
- Intermittent fasting (16x8 or at least stop eating after sun down)
- Daily morning pranayama (or 'breath work' if you prefer that term)
- Daily morning intake of copper utensil stored water (~8 hours or overnight)
- Weekly oil pulling for gum health.
This approach feels a bit stoic and neanderthal initially, less attuned to our modern and progressive society, but as effective as Ozempic in long-run (minus the side-effects or addiction).
I've been on Mounjaro for 4 months now. You normally start with an initial lower dose and increase the dose after a month. I lost 5 kg (~11 lbs) on the initial dose in the first month, and when I increased the dose, I also stopped smoking.
I've been smoking on and off for 20 years. I have stopped (and relapsed) many times, so I believe I can compare. This was a lot easier. I mean, I had cravings, but they weren't really that bad, and while the first week is generally the difficult part, I only had a couple of days with issues. I did not lose weight that month, though, which is fine as I would normally gain a lot due to compensating for cravings.
I increased the dose again and started losing weight. I guess some people gain weight when they stop using GLP-1. Even if that happens, I'm fine with stopping smoking without weight gain.
That's incredible! Smoking is the hardest one of them. Mainly because smokers tend to be skinny, as cigs kill your appetite (unlike alcoholics who tend to be fat) and all GLP-1 effects go together with the weight loss.
Congrats. Smoking is a bitch of a habit and extremely hard to quit.
Nicotine pouches (or even vaping) are astronomically less harmful than cigarettes and still work as appetite suppressors. As a bonus they are more convenient to use in public. Smokers should consider considering switching instead of quitting nicotine entirely if it's easier.
I don't know why you're getting downvoted, but I totally agree.
I used to smoke a pack a day for years, but switched to vaping in the 2010s when nicotine salt juice became more available. It was a massive quality of life improvement. Though initially this unlocked a much higher dose of nicotine I'd ever get smoking, I eventually brought it down and regardless my lungs were doing better.
Around 2020, I switched to the pouches and since then I'm down to using maybe like two a day if any at all. Since they are a slower delivery method, the nature of the cravings has changed too. I can easily hold off for hours or even days since they're less intense. I have zero desire to go back to smoking or vaping ever again. I've never experienced any oral health issues from the pouches either. X-rays on my mouth and lungs now show no damage.
The only thing I will say is nicotine itself isn't entirely harmless and can trigger some mild anxiety. It seems to be related to keeping blood cotinine levels in check.
I'd never recommend people start a nicotine habit, but I think we're at the point where it's not much worse than caffeine if you take it orally. There is some research out there about the potential benefits of both preventing dementia, but I won't link anything. People can argue about that somewhere else.
The trouble with the dementia prevention claim is that while the retrospective studies are promising, none of the RCTs really show results. You can argue this is because the RCTs don't dose enough nicotine early enough to matter, and that's likely true, but retrospective studies can turn up all sorts of phantom correlations. Right now I would say we don't know for sure, and I wouldn't recommend nicotine as a preventative measure.
I would recommend nicotine as a stimulant, though. It is a solid adjunct to caffeine.
Unfortunately, Im doing both and Im skinny :)
I was a daily drinker for many years. A "1 or 2 cocktails in the evening" type of person. (And of course, 1 cocktail often meant 2 shots, so 2 cocktails = 4 shots a night.. looking back... yikes)
I started a GLP-1 in February of 2025. Lost a bunch of weight, etc.
What I wasn't expecting was that I'd have such an easy time dropping the daily drinking habit. I'm not convinced GLP's will help if you're truly addicted to alcohol to the point where you need AA and structured programs to break free. But I do think GLP's have the potential to give you the initial "kick" you need to drop the habit if you're otherwise motivated to.
In the first few months of starting the GLP-1, I remember losing enjoyment for eating (and drinking) a lot of things, especially unhealthy stuff (unhealthy foods/drinks tend to not combine well with GLP's). The taste of a cocktail wasn't as appetizing or appealing as it used to be, hard to explain.
I'd love to see more research around this.
> I'd love to see more research around this.
Looks like we posted around the same time, but see:
https://news.ycombinator.com/item?id=46945756
Similar experience. Went through a phase of drinking once or twice a week. Started GLP-1, completely dropped the drinking habit to the point where there is zero desire of drinking.
Now, I wish it could do this for late night sugary snacks as well since that's my crux.
This was also my experience. I was a daily drinker, but once I started on tirzepatide I lost all interest. Even after I stopped taking the medicine, I still wasn't interested. I'll occasionally have a cocktail or glass of wine, but it's now a once-a-month sort of thing.
It removes my craving for alcohol, but I can definitely time my dosage effectiveness based on when I start craving beer again.
I had a very similar experience.
There is a point you made here "losing enjoyment for eating (and drinking)" that I think is The Key, but also not what people think when they hear it without experiencing it. Someone hearing that line might think it makes food "unenjoyable," as in "bad." That is not the case. It is "unenjoyable" as in "lacking in a joyful experience."
After talking with friends of mine who are similarly aged to me but have not had the major weight struggles I've had, I realized one of the biggest differences between us is not our drive or discipline (they envy me in many of these areas), it's in the sheer level of enjoyment that I get out of food and drink that they do not.
There are certain foods that, if I have them, they make me more hungry. I can't physically fit enough spaghetti or chocolate pudding into my mouth to satisfy my craving for it. My favorite beer feels glorious all the way down my throat and into my stomach; I can go from depressed to happy in 10 seconds just from that first gulp. And it's just those specific things. I'm not going to scarf down hard on lasagna or chocolate ice cream. While I enjoy whiskey, wine, cocktails, and other beers, I can have one in a night and be done.
There are also foods that are the opposite. I physically cannot stomach muscles or cuccumber. Putting cauliflower--in any form--on my plate is likely to start an argument. All leafy greens feel like a punishment; I can choke them down, unlike muscles, but I'm not going to like the person who made me do it.
But my friends without weight issues have never had these experiences with any foods. Food is just a way to avoid hunger. Booze is just a way to get drunk. There's no strong emotional connection to any of it.
And GLP-1 agonists completely remove that. I've heard it called "The Food Noise." It's basically a re-baselining of my relationship to food back to what should be "normal." Nothing has a feedback loop of pushing me to consume more anymore. Nothing gives me such strong revulsion that I can't eat it anymore. It's just food, on my plate. I don't even feel hungry, the only reason I'm eating it is because I understand at an intellectual level that I have to in order to not pass out in the middle of the day.
It just makes me eat less. I enjoy food every bit as much as I did before, just less often and in lower amounts. I still get hungry eventually and still want to eat and food tastes the same and if anything has a stronger emotional appeal than it did before because I eat so little.
I still enjoy drinking an IPA just as much, and really I enjoy it much more since I have one every few months instead of 5 every night. I could enjoy one every night, but I don't really need to have it, even though it would be delicious and the buzz is enjoyable, I just don't feel compelled to get it and I know it's not good for me. I knew before it wasn't good for me, believe me as the child of an alcoholic I knew it wasn't good to drink every night, but I did anyway because I had something inside pushing me to do it.
So maybe that is what you are describing, that thing that pushes you to do things you know are bad for you, and which you will regret immediately, but yet you feel like you have to do anyway. It's not enjoying something more, it's more like feeding withdrawal.
Overall I feel like there is someone in control now. I can just decide that drinking a beer every night is bad for me and not aligned with my goals and then I don't do it, and when I rarely think about it I'm just not a person who drinks alone anymore and my thoughts quickly move on to figuring out how to make croissant dough or looking for a scene to post to instagram or some work problem that has been bugging me.
> It just makes me eat less. I enjoy food every bit as much as I did before
Why are you eating less, if you enjoy eating just as much as before?
Is it that you feel physically full (would be uncomfortable to eat more)? Or is it that you aren't hungry (but you're also not particularly "full")?
Why don't you eat 5 entire pizzas instead of 5 slices? It's like that. One pizza seems like a LOT of food now. Three slices seems like too much. Before I could eat a whole pizza without even thinking twice. I look forward to it just as much, if not more. The first bite is just as good, but honestly seems better since I didn't just have a snack an hour ago. I ate like 5 Takis for a snack the other day and they were delicious and I really enjoyed it, but before I would have eaten the entire bag and not really even taken the time to taste them.
I would say it takes longer to get hungry even though I eat maybe 1/3 to 1/2 as many calories as I did before (that is to say 2/3 less than before). If I ate this little before GLP-1 I would have felt like I was dying and would have been thinking about food and hunger all day and night.
Yes you do fill up faster, and your stomach empties slower, so there is actually a physical 'being full' that happens with less food than previously.
I have heard a few very different experiences with GLP-1s, for some an almost magical relief from addictive behaviors, for others they didn't notice much on that front at all.
So much is about what is causing the behavior I would expect. GLP-1s don't change the way you think so much as breaking some of the trigger mechanisms.
Are you doing the action because you want to do it, or because your body is responding to that mild trigger that occurs, but your pavlonian response is so strong you can't differentiate.
The thing is, those trigger mechanisms break after weeks without doing them, whereas it is very hard to break them normally without some more extreme measure.
this is baseless speculation.
there are GLP-1 receptors on neurons, the drugs cross the blood-brain barrier, they are active in reward centers.
these drugs directly affect the behavior of neurons, it's not some chain of effects that result in behavior change
I'm in the latter group. I've had little to no weight loss from Ozempic because my issue is having a sweet tooth, not eating too much regular food. Yeah I fill up faster, but by the time I would fill up on cookies or something that's still a crazy amount of calories. So it hasn't really helped me to curb my weight. It has helped my A1c though, which is the main thing.
Without getting into individual physical differences that occur, expectation is a huge part of addiction and overcoming addiction. Rituals are very often a part of substance abuse for similar reasons. It sounds silly, but consciously placebo-ing yourself can be very effective for people trying to quit. "This medicine will cure my addiction" can be a very powerful mantra for people with a strong imagination.
ah, nope. not everything is just a placebo.
I've heard very addictive personalities describe it as a light switch being turned off, people who have been on a whole host of different things across time.
Individual differences in medication response isn't just placebo.
Why make medicine at all if essentially you think you just have to convince people of fairy stories well enough for literally anything to work?
Which is common with any medication and why medicine is so hard. Two people can react wildly different to the same drug.
I'm surprised that this article doesn't appear to mention the RCT on semaglutide and alcohol use disorder by Hendershot et al. that was published in JAMA Psychiatry in early 2025 (though it's possible I missed it) https://doi.org/10.1001/jamapsychiatry.2024.4789
This was largely portrayed as a great result in the popular press although personally I think it was a bit of a disappointment given all the amazing anecdotes https://dynomight.net/glp-1/
What made it a disappointment? Over only 9 weeks, which is a very short time for habit changes to take hold, there were measurable, statistically significant effects. And at the highest dose was just 1mg / week for one single week at the end, where the maintenance mode for many is 2.4mg / week.
Seeing such an effect in just 9 weeks, 90% of that time being at low ramp up doses, is astonishing.
The results for how much people actually drank in daily life were basically zero. No effect at all. The effects you're talking about are for a weird lab experiment where they sort of had people sit there in the lab and drink (or not). A huge percentage of people declined to participate in that experiment, too, which makes causality non-obvious.
The effects you're talking about are for a weird lab experiment where they sort of had people sit there in the lab and drink (or not).
Where people on GLP-1s -- in a randomized, double-blind study, notably -- chose to partake of less. I cannot fathom how you dismiss this.
It's a 9 week study at very low doses, and already a significant measurable effect was seen. Now if this wasn't a double-blind study I would dismiss it, but otherwise yeah, it matters.
People who have drinking habits will take a long time to adopt new habits. I would never expect to see baseline behaviour changes in so short a time. But their non-habit desire for alcohol clearly was diminished, hence the lab outcomes.
When you have lots of non-randomized dropouts from a randomized trial, that greatly weakens the causal link. The results are effectively non-randomized.
Meanwhile the evidence from actual drinking levels was much stronger (far fewer dropouts) and showed zero effect. Before this trial was done, you may have predicted that there would be positive results for the lab experiment but zero results in ecological conditions. But I think that prediction would be quite unusual. For anyone who expected results in ecological conditions (like me), this was disappointing.
https://archive.is/1Zbeg
This feels like piracy to me and an unintended usecase of archives.
I’ll admit I’ve felt a bit weird about posting archive links myself, but not weird enough to subscribe to The New Yorker instead
What do you mean? I was always under the impression that archives are for accessing a copy when the original is hard to access - this seems like the perfect use case.
Bypassing a paywall does sound a bit like piracy, if you think about it. This is what the commenter is referring to (tho in this case, I don't see a paywall on the article this end.)
Advertisements and web tracking feel like stalking. I’ll pay for content when the content providers respect my attention and privacy and not until then.
> Are paywalls ok? [0]
>> It's ok to post stories from sites with paywalls that have workarounds.
>> In comments, it's ok to ask how to read an article and to help other users do so.
[0] https://news.ycombinator.com/newsfaq.html#:~:text=Are%20payw...
IMO it’s definitely piracy, but piracy is morally neutral
Piracy is ok
This isn't archive.org. Archive.is (and its many TLD equivalents) is explicitly for bypassing paywalls like this, and this is absolutely the intended use.
9 times out of ten it's because sites use cloaking and serve up all of the contents to search bots, but then paywall out end users, so it's kind of a hoisted by their own petard kind of situation.
And, I mean, people can choose to not follow those links. To the rest of us they're often very welcome, and we aren't subscribing to every random site for the once in a millennia worthwhile article.
> is explicitly for bypassing paywalls like this
The site existed for most of a decade before it had any particular paywall bypassing. It's an ondemand archival site that saves the DOM in such a way that redisplay is faithful, unlike archive.org.
It's a key resource in court cases for purely archival purposes and the fact that it bypasses paywalls is essential for its archival purpose to function.
Yeah, sure (sarcastic). And people mostly use torrents to share Linux distros.
The site/org has no office and is anonymously run virtually. Exists on random, essentially free for all TLDs, does not honour take-down requests, does not respect robots.txt, masquerades as the Googlebot...
...yeah, I happen to have not been born yesterday so I'm not going to play along with a fiction.
That’s nice. I’m still not giving the NYT my email or a dime.
Nothing you said contradicts the post you responded to, so there's no need to be rude (e.g. sarcasm) or adversarial here. You are both correct.
Nothing I said was rude or adversarial, so not sure why you decided to be rude and adversarial here.
My sarcasm was to the purported original goal, when it has always, since day one, been a fake Googlebot known, again since day 1, as a circumvention of paywalls for sites that cloak.
well if you declare that nothing you said was rude (i.e. no sarcasm, which is rude) or adversarial, then I similarly declare that nothing I said claimed otherwise :) so what are you talking about, then?
HN is only against piracy when AI labs do it.
When giant IP corporations violate IP, that's very different from Joe Rando watching a movie for free. It's way worse, on multiple levels, for rule-makers to break rules than for ordinary people to.
> It's way worse, on multiple levels, for rule-makers to break rules than for ordinary people to.
The purpose of the system is what it does. Yet the system routinely persecutes ordinary people for this criminal offense while giant IP corporations just treat it as an opening move in corporate deal-making.
I'm contemplating GLP-1 treatment but I'm concerned that it will accidentally decrease the obsession that I have that makes me good at my job.
It's mostly appetite suppressing. Affects the perception of hunger and the brain/reward function of eating, which must also be part of what also helps for drug and alcohol addiction.
It IME doesn't act like an anti-depressant/SSRI which can affect your enthusiasm/desire for your job.
Absolutely life changing drug for me.
But what if this self-described obsession translates into burnout? Does it actually make you good or just work more compared to your peers? Can you maintain it for the rest of your career?
(I'm just concerned; I've seen many people good at and super into their job end up with burnout, often multiple times because they keep thinking "I used to be good at this!", "I enjoy this!", etc instead of accepting that it was never sustainable in the first place. I suspect people's nervous systems etc are more resilient in their 20's, which is why most people with burnout only start to run into it in their 30's)
It's a week-by-week injection - you can always stop taking it if you're unhappy with the effects.
Also in pill form now in the US. I’m on it, results were pretty quick.
Another N=1, I've noticed zero impact on my desire to engage in my normal obsessions while on GLP-1.
What GLP-1 did (initially) was give me horrible insomnia that peaked a couple of days after taking the injection so I had to time my dosage so that I suffered through that on the weekend. That got better over time and eventually went away after about 6 weeks.
Regardless, as another poster mentioned, it's a weekly injection and if you don't like the effects you can stop taking it.
I was excited about effects like this and think they’re entirely absent unless you’re obsessed with food-related app development or something else related to appetite.
N=1, I've been on GLP-1s for a long time and continue to be an obsessive.
I take it; still obsessed.
Something that has been hinted but not explicitly said: are these drugs performance enhancers? Like the same way you would take Ritalin you'd take these to curb your time wasting habits?
When the research comes in, I will be surprised if they are a performance enhancer outside the health benefits.
Meaning, it is performance-degrading to be overweight. When you remove that? you sleep better you breathe better you move better and therefore think better.
If they are directly performance enhancing, it is in an extremely subtle way- far less than a soda’s worth of caffeine.
For me they absolutely have been performance enhancing. Previously, especially in the afternoon it was hard to concentrate due to the constant cravings / constantly thinking about needing to eat something. These thoughts are completely gone, I can concentrate for hours and hours without needing to eat something. I have always only been mildly overweight, but these thoughts have been constant before I started Wegovy.
Hmm, OK. I got the impression that they might improve your conscientiousness, which for some people, that would equate to a performance enhancer.
Anecdotal, but since I’ve started Zepbound, I’ve lost 110 pounds. In that same time period, I’ve paid off and cancelled all my credit cards (except for one, which I pay off every month), filed taxes for the last five years, got a CPA on retainer, and have fixed several pressing issues around the house that I’d been studiously ignoring as they got worse.
A major part of this story I think is especially important, the last time this sort of thing happened was about a decade ago, when I lost 90 pounds without any medical intervention. At that time I learned to code, fixed up my credit, and went from being front line technical support to junior software engineer. Quite a transformative time in my life.
I think curing my sleep apnea due to substantial weight loss means I sleep better, so I just feel more ready to tackle the things the world throws at me. Weight loss is a skill I had, but it required absolute commitment to avoiding sugary foods, eating right every single day, and as soon as I strayed the weight would creep back up over the course of a year or two.
It makes me think of the huge immeasurable economic costs that are happening in the shadows because of obesity, how many people like me are there other aren’t achieving our full potential because we’re just too tired and have too much brain fog to seize the day?
FTA:
> I’d already understood addiction to be a treatable disease, not a personal failing. Still, these scans helped me appreciate how deeply addiction is rooted in neurobiology. A mere photograph of alcohol—to say nothing of a sip—was enough to send a person’s reward centers into a frenzy.
Ban alcohol advertising now and I’m not kidding or being hyperbolic.
I believe all the stories here about how these drugs helped with their addiction. However I will say I have not experienced this with food addiction which is interesting. I definitely eat less, but when I am hungry I'm still just as likely to eat peanut butter cups or french fries.
Same here. I still crave sweets like nutella before I got to bed. I just don't eat as much of it.
Seeing all these articles and studies touting GLP-1s as a magic additive to enhance health and well-being has me so skeptical that there haven't been any major downsides found yet. I guess long-term studies are necessary in order to really understand what we're getting on here.
I would love for it to be miracle it appears to be, since I hate trying to maintain my desired weight. I don't qualify for GLP-1 due to my BMI being too low, but I sure would like to stop the constant cravings for food and my love of beer. Everyday feels like a struggle to maintain a healthy lifestyle.
GLP-1s are the greatest medical innovation of the past decade. Top three, at least, mRNA might give them a run for their money.
There are known side effects, mostly gastrointestinal issues, and they don't work for everyone. That being said, I'd recommend you make your own risk assessment and consider getting on GLP-1s if you have the cash to spare. You might find that GLP-1s increase your quality of life so much that it's well-worth it (or that you get terrible nausea and immediately quit, and then you no longer need to wonder).
Potential risks have to be weighed against potential benefits. There are robust RCT results showing GLP-1s reduce all-cause mortality, major cardiovascular events, and stroke among patients with obesity or T2D by 13-14%, and suggestive evidence that some of these benefits apply to non-overweight people, though this hasn't been confirmed in RCTs and is likely smaller in magnitude.
"Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials": https://www.sciencedirect.com/science/article/pii/S266666772...
One reason to believe that cardiovascular benefits might apply to non-overweight people is that among the available evidence on overweight and obese people, weight loss doesn't seem to explain all benefits. See Figure 1 or the analysis section of the SELECT trial.
"Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial": https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
The main plausible long-term risk is thyroid cancer. Data from a meta-analysis of RCTs suggests a 55% (large error bars) increase in thyroid cancer risk.
"GLP-1 receptor agonists and the risk for cancer: A meta-analysis of randomized controlled trials": https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/do...
This is concerning, though it's worth noting that thyroid cancer is rare (1% lifetime incidence) and unlikely to kill you (98% 5-year survival, 99.9% when caught early). No studies have linked GLP-1s to a statistically significant increase in cancer-related mortality. I don't want to be too confident because RCTs have not yet shown this and I'm not an Eli Lilly shill, but cohort studies suggest GLP-1s are associated with reduced risk of other cancers. This is a good overview:
"Glucagon-like peptide-1 medicines and cancer": https://www.nature.com/articles/s43018-025-01110-1
Thanks for the thorough answer. I'm going to ask my GP and oncologist about the possibility of going on it just to see what it's like. I sure would like to drop 10 pounds and want less beer.
Smoking addiction is way harder to cope that alcohol, only surpassed by opioid. In any case a rigorous study must be performed as nowadays media hype articles about GLP1 drugs mention decline of supermarkets and increased profits by airlines because a few people lost 5-10kgs.
It’s not the cure. It’s temporary suppression. I re-sold few times monthly dose of Mounjaro and the buyers catapulted to same bad habits in no time when the last dose stopped working.
Like any medicine, it's something that is intended to be prescribed by doctors to be used under supervision, rather than just taken by people ad-hoc at a random dosage hoping for a miracle.
And as for cure rather than suppression - yes, according to that definition, no medicine that is intended to be taken indefinitely to manage a condition is a cure. But nevertheless, high blood pressure medicine, statins, anti-inflamatories, HIV antiretroviral therapy, and many other drugs have saved many millions of people from an early death. We should keep looking for one-off "cures" for all conditions, but let's not limit ourselves to them.
This is why on paper nobody is prescribed these drugs until they have followed a program to change lifestyle things like diet. You mention "re-selling Mounjaro" - which implies they just took the drugs without the programs, is that correct? Did you expect anything else?
But for many it's considered a shortcut and there's a big network of dubious online shops and weight loss clinics that sell it. It's not unlike crash / fad diets in that regard.
Most people would already benefit from lifestyle adjustments, but those are hard to do for most people - for starters, most people don't even have regular eating habits to begin with, no baseline to even make adjustments to.
Plenty of bad habits that cause chemical dependence would still benefit from a pause, even if temporary.
I'd rather use a GLP-1 for the rest of my life than use a statin for the rest of my life.
Why? Statins are one of the most well studied drugs in existence. Most people have no side effects, and the long-term benefits are incredibly straightforward - on par with blood pressure medication.
Blood pressure is a often a side effect of being overweight. But only one side effect of many. Losing weight gets rid of all side effects, not just one.
statins are blood pressure medications, mate
What is intersting is the aut-aut in the parent comment, I'd rather take drug 1 instead of drug 2 for the rest of my life
Same is true for diet and exercise
"diet" implies a temporary change to achieve a certain goal. However, "changing your diet" has long term permanence in it. But this is hard for a lot of people because they don't have a fixed diet to begin with, instead just eating whatever whenever they're hungry. Same with exercise, people need to make that into a habit.
But forming habits / making lifestyle changes is hard. And when people hear they can just take an injection instead of make lifestyle changes they're like oo, easy!
The injection doesn't mean you don't make lifestyle changes. People have this delusion that GLP-1s just make you lose weight.
They don't. People on GLP-1s lose weight the same as you or I, through diet and exercise. It just makes it easier to build those habits.
Which I think reveals the obvious. Diet and exercise ARE NOT root cause solutions. Meaning, the root cause of obesity IS NOT eating too much. Rather, it's a propensity to eat too much. And, in that regard, GLP-1s are a root cause solutions, whereas diet necessarily is not.
Same here when I start/stop Mounjaro except I continue to enjoy exercise. Though I'm probably just kidding myself that the exercise is undoing the naughty food
The only way I found to reduce cravings is to be a hermit because there is food absolutely everywhere all the time
This is exactly my experience. The only time I’ve been able to consistently lose weight was during the pandemic, when I could both work and socialize from home and strictly regulate what food came into my apartment, and when I’ve been on tirzepatide.
Relying on exercise expenditure to outrun dietary intake is a losing strategy because exercise is not an effective way to create a caloric deficit. However, it may be one of the most effective ways to defend one.
Dropping alot of weight rapidly can lead to gallbladder issues. If you're on a GLP-1 please look into this and ask your GP about potentially putting you on Urusodiol.
I saw a thread on reddit where a GP chimed in and mentioned that he was giving urusodiol to all his patients at the same time as GLPs, to help prevent the associated issues.
Either way, modern science is great. Just do your research.
It does seem like a lot of doctors prescribe GLP-1s without any corresponding education on the dietary changes one should make while on them. A friend of mine's mother was hospitalized briefly because she was basically starving herself of proper nutrition while on GLP-1s.
Since I already knew that rapid weight loss is very unhealthy, I intentionally eat very nutrient dense foods in order to keep my weight loss in a reasonable range.
Exactly why it’s on the warning labels too. But also you still need to eat which can be very hard when your body tells you no more food.
Expecting the subset of people who are obese due to inability to ignore their bodies bad signals to overeat, to have the same discipline in the opposite direction, seems foolhardy.
Every time these come up on HN everyone is willing to share their positive anecdote. What are the negative experiences that come with GLP-1s beyond relapse after stopping? I need both sides before I'd consider encouraging anyone to try it.
Rapid muscles loss, unless you are careful and managing it. In my case muscle loss led to increase, not decrease, of the lower back pain related to the crack in one of the vertebrae there. I believe that loss of core muscles increased load on the spine and caused pain. Once I started doing core exercises and cut down on dosage, pain returned back to pre glp1
been on retatrutide a couple of months, used to drink maybe 3 beers a week
now, alcohol has become the least interesting thing in the world, I just can't make myself drink it, it is so strange
No one knows of course, but it's looking likely -- anecdotal data is piling up.
That said, there are some that have reported it also lessens desire for things they want to desire.
Did a writeup on this back in summer '25:
https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-...
Paywalled so direct links to notable papers through the years below:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504
https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218
https://pubmed.ncbi.nlm.nih.gov/36031011
https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505
https://pubmed.ncbi.nlm.nih.gov/39764175
https://pubmed.ncbi.nlm.nih.gov/39032839/
https://www.science.org/content/article/obesity-drug-cuts-op... https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei... (The science.org article is paywalled IIRC)
https://pubmed.ncbi.nlm.nih.gov/39535805/
https://pubmed.ncbi.nlm.nih.gov/39937469/
Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.
Eli Lilly has taken to calling GLP1s "anti-hedonics" as well
This brings up another interesting question. What is the chemical basis of desire in the brain?
Easy, it is dopamine.
No it isn't. Every neurotransmitter is involved with every complex phenomenon.
as someone who struggles with eating too little, i will never cure my addictions :( i already have low appetite i might die on ozempic
Relevant:
Is India about to make Ozempic-like weight-loss drugs a whole lot cheaper? - https://edition.cnn.com/2026/02/07/india/india-semaglutide-p...
I had an experience similar to the article. Over 18 months, I lost about 85 lbs on Ozempic and Retatrutide. I went from struggling to walk past beer at the at the supermarket - giving in about 50% of the time - to having almost no desire to drink. I only one or two beers every few months. I haven't had a drink alone in two years, and my total alcohol consumption in that entire two year period is less than what I used to drink in a single week.
During this same period, I left an abusive marriage and started exercising extensively. While the causes are complex, I attribute the loss of desire to drink primarily to the GLP-1. Subjectively, I now see drinking as a distraction from programming and other things I enjoy. This feels like my early 20s, when I saw getting drunk as a waste of time, rather than later years when I pushed for another round.
I've found some basic lifestyle changes to be way more effective at weight-loss and inducing well-being than a drastic chemical therapy like Ozempic. Imbibe at your own risk.
- Intermittent fasting (16x8 or at least stop eating after sun down)
- Daily morning pranayama (or 'breath work' if you prefer that term)
- Daily morning intake of copper utensil stored water (~8 hours or overnight)
- Weekly oil pulling for gum health.
This approach feels a bit stoic and neanderthal initially, less attuned to our modern and progressive society, but as effective as Ozempic in long-run (minus the side-effects or addiction).