> The company says that the drug was generally well tolerated, but that’s on the oncology scale.
> ...
> He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had aqua regia thrown all over him (and apparently feels a bit like that, too). But his tumor volume has gone down by about 75%, and there’s a very strong chance that he wouldn’t still be alive at all without having gone on the drug.
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
While not fully approved, the company has early access available to people who meet the treatment criteria and would potentially benefit. Their HCP should evaluate this (it's not all types of pancreatic cancer, and it's not a silver bullet - but it looks like its double the survival time than current chemo). Hopefully this evolves into a new class of treatment.
Always baffling to me that people accuse researchers and doctors, people who have devoted their life to helping others, of brazen greed and deception. With no evidence, of course. Maybe the accusation says more about you than about them?
Derek Lowe’s writeup is good: https://www.science.org/content/blog-post/progress-against-p...
> The company says that the drug was generally well tolerated, but that’s on the oncology scale.
> ...
> He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had aqua regia thrown all over him (and apparently feels a bit like that, too). But his tumor volume has gone down by about 75%, and there’s a very strong chance that he wouldn’t still be alive at all without having gone on the drug.
The founders of Lovable and Builder.ai individually received more funds than the whole group of the researchers behind this medicine...
That’s talking about the ROI of a winning lottery ticket.
As we can’t know ahead of time which medicine works you need to fund many teams at the beginning.
Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2605555?query=fe...
If you want to see what the side effects look like, look at ex Senator Ben Sasse: https://youtu.be/7CFo6-6BN9k?si=2B3dqB4rOhAnPiZl
Totally naive question: is this a situation where stacking the drug with chemo might be even better?
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
While not fully approved, the company has early access available to people who meet the treatment criteria and would potentially benefit. Their HCP should evaluate this (it's not all types of pancreatic cancer, and it's not a silver bullet - but it looks like its double the survival time than current chemo). Hopefully this evolves into a new class of treatment.
Source article for those interested:
https://www.nejm.org/doi/full/10.1056/NEJMoa2505783
Paywalled but has a free access option if you make an account.
Always a money-generator.
Researchers need to find permanent cures.
Always baffling to me that people accuse researchers and doctors, people who have devoted their life to helping others, of brazen greed and deception. With no evidence, of course. Maybe the accusation says more about you than about them?